Highlights
- ⬆️PTT + NO bleeding
Intrinsic/contact pathway deficiencies = test artifacts
PTT 1:1 mix corrects
-Factor XII
-Prekallikrein (PK)
-High molecular weight kinogen (HMWK)
PTT 1:1 mix doesn't correct
-Lupus anticoagulant/APS
Bleeding history is more important than a lab
(View Tweet)
- For the new interns - Anticoagulant Mechanism Name Jewels!
Drugs target Xa = Xa in name
ApiXaban
BetriXaban
EdoXaban
RivaroXaban
Drugs target BOTH Xa+thrombin = PARIN (pair)
HeParin
EnoXaParin
DalteParin
Drugs target only IIa = B (2nd letter)
ArgatroBan
Bivalrudin
DaBigatran (View Tweet)
- Discovery of ITP was Epic
Dr William Harrington, a hematology fellow at WashU, injected blood from an ITP pt into himself
His plt count dropped immediately, and he was admitted to Barnes Hospital with epistaxis, gingival, rectal bleeding
1 week later his plt returned to normal
(View Tweet)
Highlights
- ⬆️PTT + NO bleeding
Intrinsic/contact pathway deficiencies = test artifacts
PTT 1:1 mix corrects
-Factor XII
-Prekallikrein (PK)
-High molecular weight kinogen (HMWK)
PTT 1:1 mix doesn't correct
-Lupus anticoagulant/APS
Bleeding history is more important than a lab
(View Tweet)
- For the new interns - Anticoagulant Mechanism Name Jewels!
Drugs target Xa = Xa in name
ApiXaban
BetriXaban
EdoXaban
RivaroXaban
Drugs target BOTH Xa+thrombin = PARIN (pair)
HeParin
EnoXaParin
DalteParin
Drugs target only IIa = B (2nd letter)
ArgatroBan
Bivalrudin
DaBigatran (View Tweet)
- Discovery of ITP was Epic
Dr William Harrington, a hematology fellow at WashU, injected blood from an ITP pt into himself
His plt count dropped immediately, and he was admitted to Barnes Hospital with epistaxis, gingival, rectal bleeding
1 week later his plt returned to normal
(View Tweet)