Local Anaesthetic Systemic Toxicity

Metadata

• Author: sciencedirect.com
• Full Title: Local Anaesthetic Systemic Toxicity
• Category: #articles
• URL: https://www.sciencedirect.com/science/article/pii/S2058534917301543

Highlights

• Neonates and infants have reduced AAG levels; indeed, the plasma concentration of AAG at birth is about half that of an adult (View Highlight)
• Pregnant patients are at an increased risk of toxicity. They have lower AAG levels; meanwhile, accelerated perfusion of sites of injection results in rapid absorption and a high peak free LA concentration (View Highlight)